GSK – The University of Dundee collaborations on Neglected Tropical Diseases (NTDs) treatments
Active Since: 2011-2022
Contributing to SDGs…
Accelerate research into discovering and developing effective Neglected Tropical Diseases (NTD) treatments.
MEMBER COMPANIES
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GlaxoSmithKline
Company Profile
PARTNER ORGANISATIONS
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Academia or research institute
University of Dundee
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Global NGOs
Wellcome Trust
Objectives
- Accelerate research into discovering and developing effective Neglected Tropical Diseases (NTD) treatments.
GSK and the Drug Discovery Unit (DDU) at the University of Dundee have a long-standing partnership to research Neglected Tropical Diseases (NTDs). In April 2017, the Wellcome Trust awarded the University of Dundee £7.9m for a joint five-project with GSK to boost efforts to find new drugs to treat some of the world’s most devastating parasitic diseases – visceral and cutaneous leishmaniasis, and Chagas’ disease.
SDGs THE PARTNERSHIP CONTRIBUTES TO
SDG 3: Good Health and Wellbeing
- 3.3: Communicable Diseases & NTDs
SDG 9: Industry Innovation and Infrastructure
SDG 10: Reduced Inequalities
SDG 17: Partnerships for the Goals
RESULTS & MILESTONES
Major highlights in results to date include reaching:
- Candidate Selection for GSK3186899 for Visceral Leishmaniasis in 2016
- Candidate Selection for GSK3494245 for Visceral Leishmaniasis in 2016
- Commit to First time in Human for GSK3186899 for Visceral Leishmaniasis in 2019
- Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis, Journal of Medicinal Chemistry
- Optimisation of a key cross-coupling reaction towards the synthesis of a promising antileishmanial compound, Tetrahedron letters
- 2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease, Bioorganic & medicinal chemistry letters
- Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis, Nature
- Antitrypanosomal 8-hydroxy-naphthyridines are chelators of divalent transition metals, Antimicrobial Agents and Chemotherapy
- Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi, Journal of Medicinal Chemistry
- Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade, PLoS Neglected Tropical Diseases
ADDITIONAL INFORMATION
FURTHER READING
Geographic Reach
Global Commitment
Disease Area
Neglected Tropical Diseases (NTDs)
- Chagas Disease
- Other