International AIDS Vaccine Initiative (IAVI)

Ensuring the development of preventive AIDS vaccines that are safe, effective, and accessible to all people.
Government 7
Private Foundation or Development Organization 5
Academia or research institute 3
Intergovernmental Organizations and Multilaterals 3
Professional and Trade Associations 1
Bilateral development organizations 6
Hospitals Health Facilities 1
Life Sciences 2
Local NGOs 3
Technology 2
Global NGOs 1
Pharma Company Foundation 1
Other Business Sector 4
  • To ensure the development of preventive AIDS vaccines that are safe, effective, and accessible to all people.
  • To invest majority of resources in the research and clinical assessment of candidate vaccines against strains of HIV that are prevalent in the developing world, where 95% of new HIV infections occur.

What are the health needs and challenges?

According to WHO, HIV continues to be a major global public health issue, having claimed more than 35 million lives so far. In 2017, 940 000 people died from HIV-related causes globally. There were approximately 36.9 million people living with HIV at the end of 2017 with 1.8 million people becoming newly infected in 2017 globally.

The most vulnerable and impoverished people in the world continue to bear the heaviest burden of this merciless disease: in Africa there were 25.7 million people living with HIV in 2017. The African region also accounts for over two thirds of the global total of new HIV infections.

The best long-term solution to the growing global AIDS epidemic is a vaccine, which does not yet exist.

Partnership activities and how they address needs and challenges

Launched in 1996, the International AIDS Vaccine Initiative (IAVI) is a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges including HIV and tuberculosis. Its mission is to translate scientific discoveries into affordable, accessible public health solutions for the people who need them most.

IAVI’s works to:

  • Discover – new approaches to developing vaccines and other means of preventing HIV.
  • Accelerate – discovery, translational and clinical research through laboratories in the US, India, Africa, and the UK.
  • Strengthen – in-country vaccine research capacity through a unique network of clinical research partners in Africa.
  • Partner – with leading scientists in academia, government, and industry in the US and Europe. IAVI applies the latest biopharmaceutical industry product development expertise to develop innovative products tailored to the needs of at-risk populations.
  • Share – IAVI’s resources with other innovators to help the HIV community as a whole succeed.
  • Extend – IAVI’s core capabilities in HIV disease prevention to solving other global health challenges.

IAVI‘s scientific team works with more than 50 academic, commercial and government institutions to develop and assess candidate HIV vaccines. IAVI has partnered with local research institutions to develop a network of sophisticated laboratories in India and in southern and eastern Africa. IAVI also has brought leading HIV researchers together into scientific consortia, including the Neutralizing Antibody Consortium and the Vectors Consortium, to address key obstacles to the development of an effective AIDS vaccine and to generate novel candidates.

Janssen Pharmaceutical Companies of Johnson & Johnson and IAVI entered into an agreement to develop an HIV vaccine based on the company’s AdVac adenovirus vector technology and obtained the rights from J&J to use a cell line for these vectors. A Phase I clinical trial evaluating safety and immunogenicity of a candidate vaccine based on this technology started in 2009.

In August 2010 Janssen and IAVI announced their participation in an international Phase I clinical trial in the United States and Africa of a combination of two Ad-based AIDS vaccine candidates, Ad26.ENVA.01 and Ad35-ENV, in healthy adults who are not infected with HIV. The clinical trial, led by IAVI has started in October 2010, representing a collaboration between IAVI, Janssen, the Ragon Institute, and Beth Israel Deaconess Medical Center (BIDMC), a major teaching hospital of Harvard Medical School.

Results and milestones

Perhaps the most critical roadblock to the development of an effective AIDS vaccine arises from HIV’s uncanny ability to avoid neutralization by antibodies. However, a handful of antibodies capable of shutting down the many variants of the virus have been isolated from HIV-infected individuals.

Work done within IAVI’s Neutralizing Antibody Consortium (NAC) has since exposed not only how each of the known neutralizing antibodies manages to shut down HIV, but also how the virus shields its vulnerable spots from immune attack. This information is now being harnessed by NAC scientists to devise new approaches to developing AIDS vaccine candidates.

Bristol Myers Squibb is a former member of this initiative.

Geographic Reach
  • Global Commitment
Disease Area
  • Infectious and Parasitic Disease
See Disease Areas
Target Population
  • Children
  • Youth
  • Men
  • People with low incomes
  • Women
Partner organizations

Ministry of Science and Technology India

Ministry of Foreign Affairs Netherlands

Ministry of Foreign Affairs Norway

Ministry of Foreign Affairs and Cooperation Spain

US National Institutes of Health (NIH)

Basque Autonomous Government

Ministry of Foreign Affairs Denmark

Private Foundation or Development Organization

James B. Pendleton Charitable Trust

Rockefeller Foundation

Starr Foundation

Bill and Melinda Gates

The Bill & Melinda Gates Foundation, along with the United Kingdom’s Department for International Development, the Directorate General for International Cooperation in the Netherlands, and the Australian Agency for International Development have provided funding to Aeras for the study.

Glickenhaus Foundation

Academia or research institute

Foundation for the National Institutes of Health

Institut Mrieux

Ragon Institute

Intergovernmental Organizations and Multilaterals

World Bank

European Union

OPEC Fund for International Development

Professional and Trade Associations

Proskauer Rose LLP

Bilateral development organizations

Canadian International Development Agency (CIDA)

Irish Aid

Norwegian Agency for Development Cooperation (Norad)

Swedish International Development Cooperation Agency (SIDA)

UK Department for International Development

The United Kingdom’s Department for International Development, the Directorate General for International Cooperation in the Netherlands, and the Australian Agency for International Development (along with the Bill & Melinda Gates Foundation) have provided funding to Aeras for the study.

US Agency for International Development (USAID)

Hospitals Health Facilities

Beth Israel Deaconess Medical Center, Harvard Medical School

Life Sciences

Thermo Fisher Scientific


Local NGOs

Broadway Cares - Equity Fights AIDS

Hale Foundation

City of New York Economic Development Corporation


BD (Becton Dickinson)


Global NGOs
International AIDS Vaccine Initiative

Aeras, and now IAVI, have provided funding and expertise for the early scientific discovery as well as support in the implementation and conduct of the clinical trials.

Pharma Company Foundation

Gilead Foundation

Other Business Sector

Carlsberg Group

Shearman & Sterling LLP

United Airlines

White & Case LLP