Preparing for Pandemic Flu
A comprehensive programme to ensure adequate stockpiling of flu treatment and licencing agreements for generic pharmaceutical manufacturers to produce generics in the case of a flu pandemic.
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The overall aim of this initiative is to strengthen global preparedness for the event of a flu pandemic.
What are the health needs and challenges?
Influenza pandemics are rare but recurring events. They have typically occurred every 10-50 years throughout recorded history. The potentially serious impacts on human health, national economies and social infrastructure are of global concern. The last of three pandemics in the 20th century originated in Hong Kong in 1968-1969, causing around one million deaths. In June 2009 the WHO declared the 21st century’s first pandemic, which officially ended in August 2010.
With the ease and speed of travel, a localised epidemic can transform into a pandemic rapidly. Hence, advance planning and preparedness are critical to help mitigate the impact. This includes stockpiling of essential antiviral medicines and vaccines.
Tamiflu (oseltamivir) is on the front line of national pandemic defense strategies. The World Health Organization (WHO), the European Centre for Disease Prevention & Control (ECDC) and the US Center for Disease Control and Prevention (CDC) have stated that Tamiflu is one of two approved antivirals with activity against the pandemic strain of H1N1 influenza virus.
Partnership activities and how they address needs and challenges
Roche works closely with the WHO to maintain Tamiflu stockpiles for distribution by the WHO to countries in need during a pandemic. The stockpiles can also be used for preventative measures to quickly contain and manage local outbreaks. Roche also works with governments, private companies and other organisations to strengthen their global pandemic preparedness.
Since 2005 Roche has provided Tamiflu capsules and active pharmaceutical ingredient to governments for use in the event of a pandemic at substantially reduced prices. Low income countries can purchase Tamiflu at further reduced prices (see pricing information on website). Roche has also developed a pandemic preparedness plan, in association with the WHO and governments, that forms the basis of many company plans.
Since some low-income countries are unable to create an adequate stockpile of Tamiflu, even with reduced prices, in 2009 the company launched the Tamiflu Reserves Program for member countries of the GAVI Alliance, excluding India. Through the program Roche offers Tamiflu at further reduced prices and a spread payment over a number of years.
In 2005, Roche granted sublicenses to three generic pharmaceutical manufacturers, Shanghai Pharmaceuticals and HEC Group in China and Hetero Pharmaceuticals in India, to produce generic Tamiflu (oseltamivir) for pandemic use in China, India and developing countries in case of a pandemic. In 2006, Roche also provided information to a South African generic pharmaceutical manufacturer, Aspen Pharmaceuticals, to allow it to produce oseltamivir for pandemic use in Africa.
Results and milestones
To help the global response to pandemic influenza, Roche has:
- Fulfilled pandemic orders for Tamiflu from more than 95 countries through differentiated pandemic pricing;
- Extended the shelf-life of Tamiflu from five to seven years;
- Granted sublicenses to the patent for oseltamivir to companies in India, China and South Africa to produce generic oseltamivir for pandemic use in these regions.
- Eastern Mediterranean
- South-East Asia
- Western Pacific
- Infectious and Parasitic Disease
SGDs the partnership contributes to
- 3.2: Reduce Under-5 Mortality
- 3.3: Communicable Diseases & NTDs
- 3.8: Achieve universal health coverage
World Health Organization (WHO)
European Centre for Disease Prevention & Control (ECDC)
Gavi, The Vaccine Alliance
Centers for Disease Control and Prevention (CDC)
Pharma (non-IFPMA member)
Other Business Sector
Hetero Drugs (India)
- Burkina Faso
- Cabo Verde
- Central African Republic
- Côte d'Ivoire
- Democratic Republic of the Congo
- Equatorial Guinea
- Sao Tome and Principe
- Sierra Leone
- South Africa
- South Sudan
- United Republic of Tanzania
- Antigua and Barbuda
- Bolivia (Plurinational State of)
- Costa Rica
- Dominican Republic
- El Salvador
- French Guiana
- Saint Kitts and Nevis
- Saint Lucia
- Saint Vincent and the Grenadines
- Trinidad and Tobago
- United States of America
- Venezuela (Bolivarian Republic of)
- Iran (Islamic Republic of)
- Saudi Arabia
- Syrian Arab Republic
- United Arab Emirates
- West Bank and Gaza
- Bosnia and Herzegovina
- Czech Republic
- Republic of Moldova
- Russian Federation
- The former Yugoslav republic of Macedonia
- United Kingdom
- Democratic People's Republic of Korea
- Sri Lanka
- Taiwan, Province of China
- Brunei Darussalam
- Cook Islands
- Hong Kong
- Lao People's Democratic Republic
- Marshall Islands
- Micronesia (Federated States of)
- New Zealand
- Papua New Guinea
- Republic of Korea
- Solomon Islands
- Viet Nam
Infectious and Parasitic Disease